(See also Overview of Delirium and Dementia Overview of Delirium and Dementia Delirium (sometimes called acute confusional state) and dementia are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition... read more .)
Dementia may occur at any age but affects primarily older people. It accounts for more than half of nursing home admissions.
Dementias can be classified in several ways:
Dementia Overview of Delirium and Dementia Delirium (sometimes called acute confusional state) and dementia are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition... read more should not be confused with delirium Delirium Delirium is an acute, transient, usually reversible, fluctuating disturbance in attention, cognition, and consciousness level. Causes include almost any disorder or drug. Diagnosis is clinical... read more , although cognition is disordered in both. The following helps distinguish them:
Other specific characteristics also help distinguish the two disorders (see table Differences Between Delirium and Dementia Differences Between Delirium and Dementia* Delirium (sometimes called acute confusional state) and dementia are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition... read more ).
Dementias may result from primary diseases of the brain or other conditions (see table Classification of Some Dementias Classification of Some Dementias Dementia is chronic, global, usually irreversible deterioration of cognition. Diagnosis is clinical; laboratory and imaging tests are usually used to identify treatable causes. Treatment is... read more ).
The most common types of dementia are
Dementia also occurs in patients with Parkinson disease Dementia with Lewy Bodies and Parkinson Disease Dementia Lewy body dementia includes clinically diagnosed dementia with Lewy bodies and Parkinson disease dementia. Dementia with Lewy bodies is chronic cognitive deterioration characterized by cellular... read more , Huntington disease Huntington Disease Huntington disease is an autosomal dominant disorder characterized by chorea, neuropsychiatric symptoms, and progressive cognitive deterioration, usually beginning during middle age. Diagnosis... read more , progressive supranuclear palsy Progressive Supranuclear Palsy (PSP) Progressive supranuclear palsy is a rare, degenerative central nervous system disorder that progressively impairs voluntary eye movements and causes bradykinesia, muscular rigidity with progressive... read more , Creutzfeldt-Jakob disease Creutzfeldt-Jakob Disease (CJD) Creutzfeldt-Jakob disease (CJD) is the most common human prion disease. It occurs worldwide and has several forms and subtypes. CJD symptoms include dementia, myoclonus, and other central nervous... read more , Gerstmann-Sträussler-Scheinker syndrome Gerstmann-Sträussler-Scheinker Disease (GSS) Gerstmann-Sträussler-Scheinker disease is an autosomal dominant prion brain disease that typically begins during middle age. (See also Overview of Prion Diseases.) Gerstmann-Sträussler-Scheinker... read more , other prion disorders Overview of Prion Diseases Prion diseases are progressive, fatal, and untreatable degenerative brain disorders. Prominent types include Creutzfeldt-Jakob disease (CJD), the prototypic example (usually sporadic) Variant... read more , neurosyphilis Syphilis is caused by the spirochete Treponema pallidum and is characterized by 3 sequential clinical, symptomatic stages separated by periods of asymptomatic latent infection. Common manifestations... read more , a traumatic brain injury (eg, chronic traumatic encephalopathy), or certain brain tumors located in cortical or subcortical brain areas involved in cognition. Patients can have > 1 type (mixed dementia).
Some structural brain disorders (eg, normal-pressure hydrocephalus Normal–Pressure Hydrocephalus Normal-pressure hydrocephalus is characterized by gait disturbance, urinary incontinence, dementia, enlarged brain ventricles, and normal or slightly elevated cerebrospinal fluid pressure. ... read more , subdural hematoma Traumatic brain injury (TBI) is physical injury to brain tissue that temporarily or permanently impairs brain function. Diagnosis is suspected clinically and confirmed by imaging (primarily... read more ), metabolic disorders (eg, hypothyroidism Hypothyroidism Hypothyroidism is thyroid hormone deficiency. It is diagnosed by clinical features such as a typical facial appearance, hoarse slow speech, and dry skin and by low levels of thyroid hormones... read more , vitamin B12 deficiency Vitamin B12 Deficiency Dietary vitamin B12 deficiency usually results from inadequate absorption, but deficiency can develop in vegans who do not take vitamin supplements. Deficiency causes megaloblastic anemia, damage... read more ), and toxins (eg, lead Lead Poisoning Lead poisoning often causes minimal symptoms at first but can cause acute encephalopathy or irreversible organ damage, commonly resulting in cognitive deficits in children. Diagnosis is by whole... read more ) cause a slow deterioration of cognition that may resolve with treatment. This impairment is sometimes called reversible dementia, but some experts restrict the term dementia to irreversible cognitive deterioration.
Depression Depressive Disorders Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more may mimic dementia (and was formerly called pseudodementia); the two disorders often coexist. However, depression may be the first manifestation of dementia.
Age-associated memory impairment refers to changes in cognition that occur with aging. Older people have a relative deficiency in recall, particularly in speed of recall, compared with recall during their youth. These changes do not affect daily functioning and thus do not indicate dementia. However, the earliest manifestations of dementia are very similar.
Mild cognitive impairment (MCI) causes greater memory loss than age-associated memory impairment; memory and sometimes other cognitive functions are worse in patients with this disorder than in age-matched controls, but daily functioning is typically not affected. In contrast, dementia impairs daily functioning. Up to 50% of patients with mild cognitive impairment develop dementia within 3 years.
Subjective cognitive decline (SCD), a relatively new term, is defined as a self-experienced persistent decline in cognitive capacity but normal performance on standardized cognitive tests used to classify mild cognitive impairment (1 Etiology reference Dementia is chronic, global, usually irreversible deterioration of cognition. Diagnosis is clinical; laboratory and imaging tests are usually used to identify treatable causes. Treatment is... read more ). The risk of MCI and dementia is increased in people with subjective cognitive decline.
Any disorder may exacerbate cognitive deficits in patients with dementia. Delirium often occurs in patients with dementia.
Drugs, particularly benzodiazepines and anticholinergics (eg, some tricyclic antidepressants, antihistamines, antipsychotics, benztropine), may temporarily cause or worsen symptoms of dementia, as may alcohol, even in moderate amounts. New or progressive kidney or liver failure may reduce drug clearance and cause drug toxicity after years of taking a stable drug dose (eg, of propranolol).
Prion Overview of Prion Diseases Prion diseases are progressive, fatal, and untreatable degenerative brain disorders. Prominent types include Creutzfeldt-Jakob disease (CJD), the prototypic example (usually sporadic) Variant... read more mechanisms appear to be involved in most or all neurodegenerative disorders that first manifest in older patients. A normal cellular protein sporadically (or via an inherited mutation) becomes misfolded into a pathogenic form or prion. The prion then acts as a template, causing other proteins to misfold similarly. This process occurs over years and in many parts of the central nervous system (CNS). Many of these prions become insoluble and, like amyloid, cannot be readily cleared by the cell. Evidence implies prion or similar mechanisms in Alzheimer disease (strongly), as well as in Parkinson disease, Huntington disease, frontotemporal dementia, and amyotrophic lateral sclerosis. These prions are not as infectious as those in Creutzfeld-Jacob disease, but they can be transmitted.
(See also Behavioral and Psychologic Symptoms of Dementia Behavioral and Psychologic Symptoms of Dementia Disruptive actions are common among patients with dementia and are the primary reason for up to 50% of nursing home admissions. Disruptive actions include wandering, restlessness, yelling, throwing... read more .)
Dementia impairs cognition globally. Onset is gradual, although family members may suddenly notice deficits (eg, when function becomes impaired). Often, loss of short-term memory is the first sign. At first, early symptoms may be indistinguishable from those of age-associated memory impairment or mild cognitive impairment, but then progression becomes apparent.
Although symptoms of dementia exist in a continuum, they can be divided into
Personality changes and behavioral disturbances may develop early or late. Motor and other focal neurologic deficits occur at different stages, depending on the type of dementia; they occur early in vascular dementia and late in Alzheimer disease. Incidence of seizures is somewhat increased during all stages.
Psychosis—hallucinations, delusions, or paranoia—occurs in about 10% of patients with dementia, although a higher percentage may experience these symptoms temporarily.
Many disorders, particularly during exacerbations, can worsen the symptoms of dementia. These disorders include diabetes Evaluation of the Patient With a Liver Disorder History and physical examination often suggest a cause of potential liver disorders and narrow the scope of testing for hepatic and biliary disorders. Various symptoms may develop, but few are... read more , chronic bronchitis Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. Alpha-1 antitrypsin deficiency and various occupational... read more , emphysema Chronic obstructive pulmonary disease (COPD) is airflow limitation caused by an inflammatory response to inhaled toxins, often cigarette smoke. Alpha-1 antitrypsin deficiency and various occupational... read more , infections, chronic kidney disease Chronic Kidney Disease Chronic kidney disease (CKD) is long-standing, progressive deterioration of renal function. Symptoms develop slowly and in advanced stages include anorexia, nausea, vomiting, stomatitis, dysgeusia... read more , liver disorders Evaluation of the Patient With a Liver Disorder History and physical examination often suggest a cause of potential liver disorders and narrow the scope of testing for hepatic and biliary disorders. Various symptoms may develop, but few are... read more , and heart failure Heart Failure (HF) Heart failure (HF) is a syndrome of ventricular dysfunction. Left ventricular failure causes shortness of breath and fatigue, and right ventricular failure causes peripheral and abdominal fluid... read more .
Drinking alcohol Alcohol Use Disorders and Rehabilitation Alcohol use disorder involves a pattern of alcohol use that typically includes craving and manifestations of tolerance and/or withdrawal along with adverse psychosocial consequences. Alcoholism... read more , even in moderate amounts, may also worsen the symptoms of dementia and contribute to its progression (eg, by reducing brain volume), and most experts recommend that patients with dementia stop drinking alcohol.
Recent memory is impaired; learning and retaining new information become difficult. Language problems (especially with word finding), mood swings, and personality changes develop. Patients may have progressive difficulty with independent activities of daily living (eg, balancing their checkbook, finding their way around, remembering where they put things). Abstract thinking, insight, or judgment may be impaired. Patients may respond to loss of independence and memory with irritability, hostility, and agitation.
Functional ability may be further limited by the following:
Agnosia Agnosia Agnosia is inability to identify an object using one or more of the senses. Diagnosis is clinical, often including neuropsychologic testing, with brain imaging (eg, CT, MRI) to identify the... read more : Impaired ability to identify objects despite intact sensory function
Apraxia Apraxia Apraxia is inability to execute purposeful, previously learned motor tasks, despite physical ability and willingness, as a result of brain damage. Diagnosis is clinical, often including neuropsychologic... read more : Impaired ability to do previously learned motor activities despite intact motor function
Although early dementia may not compromise sociability, family members may report strange behavior accompanied by emotional lability.
Patients become unable to learn and recall new information. Memory of remote events is reduced but not totally lost. Patients may require help with basic activities of daily living (eg, bathing, eating, dressing, toileting).
Personality changes may progress. Patients may become irritable, anxious, self-centered, inflexible, or angry more easily, or they may become more passive, with a flat affect, depression, indecisiveness, lack of spontaneity, or general withdrawal from social situations. Personality traits or habits may become more exaggerated (eg, concern with money becomes obsession with it).
Behavior disorders Behavioral and Psychologic Symptoms of Dementia Disruptive actions are common among patients with dementia and are the primary reason for up to 50% of nursing home admissions. Disruptive actions include wandering, restlessness, yelling, throwing... read more may develop: Patients may wander or become suddenly and inappropriately agitated, hostile, uncooperative, or physically aggressive.
By this stage, patients have lost all sense of time and place because they cannot effectively use normal environmental and social cues. Patients often get lost; they may be unable to find their own bedroom or bathroom. They remain ambulatory but are at risk of falls or accidents secondary to confusion.
Altered sensation or perception may culminate in psychosis with hallucinations and paranoid and persecutory delusions.
Sleep patterns are often disorganized.
Patients cannot walk, feed themselves, or do any other activities of daily living; they may become incontinent. Recent and remote memory is completely lost. Patients may be unable to swallow. They are at risk of undernutrition, pneumonia (especially due to aspiration), and pressure ulcers. Because they depend completely on others for care, placement in a long-term care facility often becomes necessary. Eventually, patients become mute.
Because such patients cannot relate any symptoms to a physician and because older patients often have no febrile or leukocytic response to infection, a physician must rely on experience and acumen whenever a patient appears ill.
End-stage dementia results in coma and death, usually due to infection.
Recommendations about diagnosis of dementia are available from the American Academy of Neurology (see also The diagnosis of dementia due to Alzheimer’s disease).
Distinguishing type or cause of dementia can be difficult; definitive diagnosis often requires postmortem pathologic examination of brain tissue. Thus, clinical diagnosis focuses on distinguishing dementia from delirium and other disorders and identifying the cerebral areas affected and potentially reversible causes.
Dementia must be distinguished from the following:
Delirium Delirium Delirium is an acute, transient, usually reversible, fluctuating disturbance in attention, cognition, and consciousness level. Causes include almost any disorder or drug. Diagnosis is clinical... read more : Distinguishing between dementia and delirium is crucial (because delirium is usually reversible with prompt treatment) but can be difficult. Attention is assessed first. If a patient is inattentive, the diagnosis is likely to be delirium, although advanced dementia also severely impairs attention. Other features that suggest delirium rather than dementia (eg, duration of cognitive impairment—see table Differences Between Delirium and Dementia Differences Between Delirium and Dementia* Delirium (sometimes called acute confusional state) and dementia are the most common causes of cognitive impairment, although affective disorders (eg, depression) can also disrupt cognition... read more ) are determined by the history, physical examination, and tests for specific causes.
Age-associated memory impairment: Memory impairment does not affect daily functioning. If affected people are given enough time to learn new information, their intellectual performance is good.
Mild cognitive impairment: Memory and/or other cognitive functions are impaired, but impairment is not severe enough to interfere with daily activities.
Cognitive symptoms related to depression: This cognitive disturbance resolves with treatment of depression. Depressed older patients may experience cognitive decline, but unlike patients with dementia, they tend to exaggerate their memory loss and rarely forget important current events or personal matters. Neurologic examinations are normal except for signs of psychomotor slowing. When tested, patients with depression make little effort to respond, but those with dementia often try hard but respond incorrectly. When depression and dementia coexist, treating depression does not fully restore cognition.
The most recent National Institute on Aging–Alzheimer's Association diagnostic guidelines specify that a general diagnosis of dementia requires all of the following:
The cognitive or behavioral impairment should be diagnosed based on a combination of history from the patient and from someone who knows the patient plus assessment of cognitive function (a bedside mental status examination or, if bedside testing is inconclusive, formal neuropsychologic testing). In addition, the impairment should involve ≥ 2 of the following domains:
Impaired ability to acquire and remember new information (eg, asking repetitive questions, frequently misplacing objects or forgetting appointments)
Impaired reasoning and handling of complex tasks and poor judgment (eg, being unable to manage a bank account, making poor financial decisions)
Language dysfunction (eg, difficulty thinking of common words, errors speaking and/or writing)
Visuospatial dysfunction (eg, inability to recognize faces or common objects)
Changes in personality, behavior, or comportment
If cognitive impairment is confirmed, history and physical examination should then focus on signs of treatable disorders that cause cognitive impairment (eg, vitamin B12 deficiency Vitamin B12 Deficiency Dietary vitamin B12 deficiency usually results from inadequate absorption, but deficiency can develop in vegans who do not take vitamin supplements. Deficiency causes megaloblastic anemia, damage... read more , neurosyphilis Syphilis is caused by the spirochete Treponema pallidum and is characterized by 3 sequential clinical, symptomatic stages separated by periods of asymptomatic latent infection. Common manifestations... read more , hypothyroidism Hypothyroidism Hypothyroidism is thyroid hormone deficiency. It is diagnosed by clinical features such as a typical facial appearance, hoarse slow speech, and dry skin and by low levels of thyroid hormones... read more , depression Depressive Disorders Depressive disorders are characterized by sadness severe enough or persistent enough to interfere with function and often by decreased interest or pleasure in activities. Exact cause is unknown... read more —see table Causes of Delirium Causes of Delirium Delirium is an acute, transient, usually reversible, fluctuating disturbance in attention, cognition, and consciousness level. Causes include almost any disorder or drug. Diagnosis is clinical... read more ).
The Mini-Mental Status Examination (see sidebar Examination of Mental Status Examination of Mental Status The patient’s attention span is assessed first; an inattentive patient cannot cooperate fully and hinders testing. Any hint of cognitive decline requires examination of mental status (see Examination... read more ) or the Montreal Cognitive Assessment (MoCA) is often used as a bedside screening test. When delirium is absent, the presence of multiple deficits, particularly in patients with an average or a higher level of education, suggests dementia. The best screening test for memory is a short-term memory test (eg, registering 3 objects and recalling them after 5 minutes); patients with dementia fail this test. Another test of mental status assesses the ability to name multiple objects within categories (eg, lists of animals, plants, or pieces of furniture). Patients with dementia struggle to name a few; those without dementia easily name many.
Neuropsychologic testing should be done when history and bedside mental status testing are not conclusive. It evaluates mood as well as multiple cognitive domains. It takes 1 to 3 hours to complete and is done or supervised by a neuropsychologist. Such testing helps primarily in differentiating the following:
Age-associated memory impairment, mild cognitive impairment, and dementia, particularly when cognition is only slightly impaired or when the patient or family members are anxious for reassurance
Dementia and focal syndromes of cognitive impairment (eg, amnesia, aphasia, apraxia, visuospatial difficulties, impairment of executive function) when the distinction is not clinically evident
Testing may also help characterize specific deficits due to dementia, and it may detect depression or a personality disorder that is contributing to poor cognitive performance.
Tests should include thyroid-stimulating hormone and vitamin B12 levels. Routine complete blood count (CBC), kidney and liver function tests are sometimes recommended, but yield is very low.
If clinical findings suggest a specific disorder, other tests (eg, for HIV or syphilis) are indicated. Lumbar puncture should be considered if a chronic infection or neurosyphilis is suspected or if prion disease or an autoimmune disorder is suspected in patients with rapidly progressive dementia. Other tests may be used to exclude causes of delirium.
Biomarkers for Alzheimer disease can be useful in research settings but are not yet routine in clinical practice. For example, in the cerebrospinal fluid (CSF), the tau level increases and beta-amyloid decreases as Alzheimer disease progresses. Also, for people with two epsilon-4 alleles of the apolipoprotein E4 gene, the risk of developing Alzheimer disease by age 75 is 10 to 30 times greater than that for people without the allele. However, routine genetic testing for the apolipoprotein E4 allele (apo epsilon-4) is not recommended, because the E4 allele is neither necessary nor sufficient to cause Alzheimer disease and because currently, no treatment can prevent or slow the progression of Alzheimer disease.
CT or MRI should be done in the initial evaluation of dementia, after any unexplained change in cognition or mental status. Neuroimaging can identify potentially reversible structural disorders (eg, normal-pressure hydrocephalus Normal–Pressure Hydrocephalus Normal-pressure hydrocephalus is characterized by gait disturbance, urinary incontinence, dementia, enlarged brain ventricles, and normal or slightly elevated cerebrospinal fluid pressure. ... read more , brain tumors Overview of Intracranial Tumors Intracranial tumors may involve the brain or other structures (eg, cranial nerves, meninges). The tumors usually develop during early or middle adulthood but may develop at any age; they are... read more , subdural hematoma Traumatic brain injury (TBI) is physical injury to brain tissue that temporarily or permanently impairs brain function. Diagnosis is suspected clinically and confirmed by imaging (primarily... read more ) and certain metabolic disorders (eg, Hallervorden-Spatz disease, Wilson disease Wilson Disease Wilson disease results in accumulation of copper in the liver and other organs. Hepatic or neurologic symptoms develop. Diagnosis is based on a low serum ceruloplasmin level, high urinary excretion... read more ) and irreversible disorders (eg, stroke Overview of Stroke Strokes are a heterogeneous group of disorders involving sudden, focal interruption of cerebral blood flow that causes neurologic deficit. Strokes can be Ischemic (80%), typically resulting... read more , leukodystrophy, Creutzfeld-Jacob disease Creutzfeldt-Jakob Disease (CJD) Creutzfeldt-Jakob disease (CJD) is the most common human prion disease. It occurs worldwide and has several forms and subtypes. CJD symptoms include dementia, myoclonus, and other central nervous... read more ).
Occasionally, electroencephalography (EEG) is useful (eg, to evaluate episodic lapses in attention or bizarre behavior).
PET with fluorine-18 (18F)–labeled deoxyglucose (fluorodeoxyglucose, or FDG) or single-photon emission CT (SPECT) can provide information about cerebral perfusion patterns and help with differential diagnosis (eg, in differentiating Alzheimer disease from frontotemporal dementia and dementia with Lewy bodies).
Amyloid radioactive tracers that bind specifically to beta-amyloid plaques (eg, fluorine-18 [18F] florbetapir, [18F] flutemetamol, [18F] florbetaben) have been used with positron emission tomography (PET) to image amyloid plaques in patients with mild cognitive impairment or dementia. This testing should be used when the cause of cognitive impairment (eg, mild cognitive impairment or dementia) is uncertain after a comprehensive evaluation and when Alzheimer disease is a diagnostic consideration. Determining amyloid status via PET is expected to increase the certainty of diagnosis and management. [18F] flortaucipir-PET, using a tau radioactive tracer, can be used to estimate the density and distribution of aggregated tau neurofibrillary tangles in adults who have cognitive impairment and are being evaluated for Alzheimer disease (1 Diagnosis reference Dementia is chronic, global, usually irreversible deterioration of cognition. Diagnosis is clinical; laboratory and imaging tests are usually used to identify treatable causes. Treatment is... read more ).
1. Fleisher AS, Pontecorvo MJ, Devous Sr MD, et al: Positron emission tomography imaging with [18F] flortaucipir and postmortem assessment of Alzheimer disease neuropathologic changes. JAMA Neurol. Published online April 27, 2020. doi:10.1001/jamaneurol.2020.0528
Recommendations about treatment of dementia are available from the National Institute for Health and Care Excellence. Measures to ensure patient safety and to provide an appropriate environment are essential to treatment, as is caregiver assistance. Several drugs are available.
Occupational and physical therapists can evaluate the home for safety; the goals are to
How well patients function in various settings (ie, kitchen, automobile) should be evaluated using simulations. If patients have deficits and remain in the same environment, protective measures (eg, hiding knives, unplugging the stove, removing the car, confiscating car keys) may be required. Some states require physicians to notify the Department of Motor Vehicles of patients with dementia because at some point, such patients can no longer drive safely.
If patients wander, signal monitoring systems can be installed, or patients can be registered in the Safe Return program. Information is available from the Alzheimer’s Association.
Ultimately, assistance (eg, housekeepers, home health aides) or a change of environment (living facilities without stairs, assisted-living facility, skilled nursing facility) may be indicated.
Patients with mild to moderate dementia usually function best in familiar surroundings.
Whether at home or in an institution, the environment should be designed to help preserve feelings of self-control and personal dignity by providing the following:
Orientation can be reinforced by placing large calendars and clocks in the room and establishing a routine for daily activities; medical staff members can wear large name tags and repeatedly introduce themselves. Changes in surroundings, routines, or people should be explained to patients precisely and simply, omitting nonessential procedures. Patients require time to adjust and become familiar with the changes. Telling patients about what is going to happen (eg, about a bath or feeding) may avert resistance or violent reactions. Frequent visits by staff members and familiar people encourage patients to remain social.
The room should be reasonably bright and contain sensory stimuli (eg, radio, television, night-light) to help patients remain oriented and focus their attention. Quiet, dark, private rooms should be avoided.
Activities can help patients function better; those related to interests before dementia began are good choices. Activities should be enjoyable, provide some stimulation, but not involve too many choices or challenges.
Exercise to reduce restlessness, improve balance, and maintain cardiovascular tone should be done daily. Exercise can also help improve sleep and manage behavior disorders.
Occupational therapy and music therapy help maintain fine motor control and provides nonverbal stimulation.
Group therapy (eg, reminiscence therapy, socialization activities) may help maintain conversational and interpersonal skills.
Eliminating or limiting drugs with central nervous system (CNS) activity often improves function. Sedating and anticholinergic drugs, which tend to worsen dementia, should be avoided.
The cholinesterase inhibitors Alzheimer disease causes progressive cognitive deterioration and is characterized by beta-amyloid deposits and neurofibrillary tangles in the cerebral cortex and subcortical gray matter. Diagnosis... read more donepezil, rivastigmine, and galantamine are somewhat effective in improving cognitive function in patients with Alzheimer disease or dementia with Lewy bodies and may be useful in other forms of dementia. These drugs inhibit acetylcholinesterase, increasing the acetylcholine level in the brain.
Memantine, an NMDA (N-methyl-d-aspartate) antagonist, may help slow the loss of cognitive function in patients with moderate to severe dementia and may be synergistic when used with a cholinesterase inhibitor.
Drugs to control behavior disorders Use of drugs Disruptive actions are common among patients with dementia and are the primary reason for up to 50% of nursing home admissions. Disruptive actions include wandering, restlessness, yelling, throwing... read more (eg, antipsychotics) have been used.
Patients with dementia and signs of depression should be treated with nonanticholinergic antidepressants, preferably selective serotonin reuptake inhibitor (SSRIs) Selective Serotonin Reuptake Inhibitors (SSRIs) Several drug classes and drugs can be used to treat depression: Selective serotonin reuptake inhibitors (SSRIs) Serotonin modulators (5-HT2 blockers) Serotonin-norepinephrine reuptake inhibitors... read more .
Immediate family members are largely responsible for care of a patient with dementia (see Family Caregiving for Older Adults Family Caregiving for Older Adults Family caregivers play a key role in delaying and possibly preventing institutionalization of chronically ill older patients. Although neighbors and friends may help, about 80% of help in the... read more ). Nurses and social workers can teach them and other caregivers how to best meet the patient’s needs (eg, how to deal with daily care and handle financial issues); teaching should be ongoing. Other resources (eg, support groups, educational materials, Internet web sites) are available.
Caregivers may experience substantial stress. Stress may be caused by worry about protecting the patient and by frustration, exhaustion, anger, and resentment from having to do so much to care for someone. Health care practitioners should watch for early symptoms of caregiver stress and burnout and, when needed, suggest support services (eg, social worker, nutritionist, nurse, home health aide).
If a patient with dementia has an unusual injury, the possibility of elder abuse Elder Abuse Elder abuse is physical or psychologic mistreatment, neglect, or financial exploitation of older adults. Common types of elder abuse include physical abuse, psychologic abuse, neglect, and financial... read more should be investigated.
Because insight and judgment deteriorate in patients with dementia, appointment of a family member, guardian, or lawyer to oversee finances may be necessary. Early in dementia, before the patient is incapacitated, the patient’s wishes about care should be clarified, and financial and legal arrangements (eg, durable power of attorney, durable power of attorney for health care Durable power of attorney for health care Advance directives are legal documents that extend a person's control over health care decisions in the event that the person becomes incapacitated. They are called advance directives because... read more ) should be made. When these documents are signed, the patient’s capacity Capacity (Competence) and Incapacity Historically, “incapacity” was considered primarily a clinical finding, and “incompetency” was considered a legal finding. That distinction, at least in terminology, is no longer firmly recognized... read more should be evaluated, and evaluation results recorded. Decisions about artificial feeding and treatment of acute disorders are best made before the need develops.
In advanced dementia, palliative measures Palliative Care and Hospice Dying patients can have needs that differ from those of other patients. So that their needs can be met, dying patients must first be identified. Before death, patients tend to follow 1 of 3... read more may be more appropriate than highly aggressive interventions or hospital care.
Dementia, unlike age-associated memory loss and mild cognitive impairment, causes cognitive impairments that interfere with daily functioning.
Be aware that family members may report sudden onset of symptoms only because they suddenly recognized gradually developing symptoms.
Consider reversible causes of cognitive decline, such as structural brain disorders (eg, normal-pressure hydrocephalus, subdural hematoma), metabolic disorders (eg, hypothyroidism, vitamin B12 deficiency), drugs, depression, and toxins (eg, lead).
Do bedside mental status testing and, if necessary, formal neuropsychologic testing to confirm that cognitive function is impaired in ≥ 2 domains.
Recommend or help arrange measures to maximize patient safety, to provide a familiar and comfortable environment for the patient, and to provide support for caregivers.
Consider adjunctive drug therapy, and recommend making end-of-life arrangements.
The following are some English-language resources that may be useful. Please note that THE MANUAL is not responsible for the content of these resources.
Alzheimer’s Association: This web site provides information about Alzheimer disease (eg, statistics, causes, risk factors, and symptoms) and resources for support (eg, information about daily care of people with Alzheimer disease and care for the caregiver).
American Academy of Neurology: Practice parameter: Diagnosis of dementia (an evidence-based review): This 2001 review makes detailed recommendations for diagnosis of dementia and identification of its cause.
Alzheimer’s Association: Dementia diagnosis: This web site provides links to free-access articles with the latest research about diagnostic criteria for Alzheimer disease and information about differential diagnosis, videos showing the disclosure of the diagnosis to patients, and up-to-date information about use of advanced imaging and biomarkers in the diagnosis of Alzheimer disease.
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