Merck Manual

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Uncommon Gastritis Syndromes


Nimish Vakil

, MD, University of Wisconsin School of Medicine and Public Health

Reviewed/Revised Mar 2023

Ménétrier Disease

This rare idiopathic disorder affects adults aged 30 to 60 and is more common among men. It manifests as a significant thickening of the gastric folds of the gastric body but not the antrum. Gland atrophy and marked foveolar pit hyperplasia occur, often accompanied by mucous gland metaplasia and increased mucosal thickness with little inflammation. Hypoalbuminemia (the most consistent laboratory abnormality) caused by gastrointestinal protein loss may be present (protein-losing gastropathy). As the disease progresses, the secretion of acid and pepsin decreases, causing hypochlorhydria.

Symptoms of Ménétrier disease are nonspecific and commonly include epigastric pain, nausea, weight loss, edema, and diarrhea.

Diagnosis of Ménétrier disease is made by endoscopy with deep mucosal biopsy or full-thickness laparoscopic gastric biopsy.

Differential diagnosis includes the following:

Various treatments have been used, including anticholinergics, antisecretory medications, and corticosteroids, but none have proved fully effective. Partial or complete gastric resection may be necessary in cases of severe hypoalbuminemia.

Eosinophilic Gastritis

Extensive infiltration of the mucosa, submucosa, and muscle layers with eosinophils often occurs in the antrum. It is usually idiopathic but may result from nematode infestation.

Symptoms of eosinophilic gastritis include nausea, vomiting, and early satiety.

Diagnosis of eosinophilic gastritis is by endoscopic biopsy of involved areas.

Corticosteroids can be successful in idiopathic cases; however, if pyloric obstruction develops, surgery may be required.

Mucosa-Associated Lymphoid Tissue (MALT) Lymphoma

Gastritis Caused by Systemic Disorders

Gastritis Caused by Physical Agents

Radiation and ingestion of corrosives (especially acidic compounds) can cause gastritis. Exposure to > 6 gray of whole-body radiation (see Acute radiation syndromes Acute radiation syndromes (ARS) Ionizing radiation injures tissues variably, depending on factors such as radiation dose, rate of exposure, type of radiation, and part of the body exposed. Symptoms may be local (eg, burns)... read more Acute radiation syndromes (ARS) ) causes marked deep gastritis, usually involving the antrum more than the corpus. Pyloric stenosis and perforation are possible complications of radiation-induced gastritis.

Infectious (Septic) Gastritis

Except for H. pylori infection Helicobacter pylori Infection Helicobacter pylori is a common gastric pathogen that causes gastritis, peptic ulcer disease, gastric adenocarcinoma, and low-grade gastric lymphoma. Infection may be asymptomatic or... read more , bacterial invasion of the stomach is rare and mainly occurs after ischemia, ingestion of corrosives, or exposure to radiation. On x-ray, gas outlines the mucosa. The condition can manifest as an acute surgical abdomen and has a very high mortality rate. Surgery is often necessary.

NOTE: This is the Professional Version. CONSUMERS: View Consumer Version
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