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James Garrity

, MD, Mayo Clinic College of Medicine and Science

Last full review/revision Sep 2021| Content last modified Oct 2021
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Papilledema is swelling of the optic disk due to increased intracranial pressure. Optic disk swelling resulting from causes that do not involve increased intracranial pressure (eg, malignant hypertension, thrombosis of the central retinal vein) is not considered papilledema. There are no early symptoms, although vision may be disturbed for a few seconds. Papilledema requires an immediate search for the cause. Diagnosis is by ophthalmoscopy with further tests, usually brain imaging and sometimes subsequent lumbar puncture, to determine cause. Treatment is directed at the underlying condition.

Papilledema is a sign of elevated intracranial pressure and is almost always bilateral. Causes include the following:

Symptoms and Signs of Papilledema

In patients with papilledema, vision is usually not affected initially, but seconds-long graying out of vision, flickering, or blurred or double vision may occur. Patients may have symptoms of increased intracranial pressure, such as headache or nausea and vomiting. Pain is absent.

Ophthalmoscopic examination reveals engorged and tortuous retinal veins, a hyperemic and swollen optic disk (optic nerve head), and retinal hemorrhages around the disk but not into the retinal periphery. Isolated disk edema (eg, caused by optic neuritis or ischemic optic neuropathy) without the retinal findings indicative of elevated cerebrospinal fluid pressure is not considered papilledema (unless the intracranial pressure is elevated on concurrent lumbar puncture).

In the early stages of papilledema, visual acuity and pupillary response to light are usually normal and become abnormal only after the condition is well advanced. Visual field testing may detect an enlarged blind spot. Later, visual field testing may show defects typical of nerve fiber bundle defects and loss of peripheral vision.

Diagnosis of Papilledema

  • Clinical evaluation

  • Immediate neuroimaging

The degree of disk swelling can be quantified by comparing the plus lens numbers needed to focus an ophthalmoscope on the most elevated portion of the disk and on the unaffected portion of the retina. Swelling can also be quantified by measuring nerve fiber layer thickness using optical coherence tomography Optical coherence tomography The eye can be examined with routine equipment, including a standard ophthalmoscope; thorough examination requires special equipment and evaluation by an ophthalmologist. History includes location... read more (OCT); OCT is done to quantify the degree of papilledema so that changes can be monitored.

Differentiating papilledema from other causes of a swollen optic disk, such as optic neuritis Optic Neuritis Optic neuritis is inflammation of the optic nerve. Symptoms are usually unilateral, with eye pain and partial or complete vision loss. Diagnosis is primarily clinical. Treatment is directed... read more , ischemic optic neuropathy Ischemic Optic Neuropathy Ischemic optic neuropathy is infarction of the optic disk. It can be arteritic or nonarteritic. The only constant symptom is painless vision loss. Diagnosis is clinical. Treatment for the nonarteritic... read more , hypotony (intraocular pressure 5 mm Hg), central retinal vein occlusion Central Retinal Vein Occlusion and Branch Retinal Vein Occlusion Central retinal vein occlusion is a blockage of the central retinal vein by a thrombus. It causes painless vision loss, ranging from mild to severe, and usually occurs suddenly. Diagnosis is... read more Central Retinal Vein Occlusion and Branch Retinal Vein Occlusion , uveitis Overview of Uveitis Uveitis is defined as inflammation of the uveal tract—the iris, ciliary body, and choroid. However, the retina and fluid within the anterior chamber and vitreous are often involved as well.... read more Overview of Uveitis , or pseudo swollen disks (eg, optic nerve drusen), requires a thorough ophthalmologic evaluation. If papilledema is suspected clinically, magnetic resonance imaging (MRI) with gadolinium contrast or computed tomography (CT) with contrast is done immediately to exclude causes such as an intracranial mass or dural venous sinus thrombosis. Lumbar puncture Post–Lumbar Puncture and Other Low–Pressure Headaches Low-pressure headaches result from reduction in cerebrospinal fluid (CSF) volume and pressure due to lumbar puncture or spontaneous or traumatic CSF leaks. (See also Approach to the Patient... read more with measurement of CSF pressure and analysis of CSF should be done if a mass lesion has been ruled out. Lumbar puncture in patients with intracranial mass lesions can result in brain stem herniation. B-scan ultrasonography and fundus autofluorescence are the best diagnostic tools for the pseudo disk edema of optic nerve drusen.

Treatment of Papilledema

  • Treatment of underlying disorder

Urgent treatment of the underlying disorder is indicated to decrease intracranial pressure. If intracranial pressure is not reduced, secondary optic nerve atrophy and vision loss eventually occur, along with other serious neurologic sequelae.

Key Points

  • Papilledema indicates increased intracranial pressure.

  • In addition to bilateral hyperemic and swollen optic disks (optic nerve heads), patients typically have engorged and tortuous retinal veins, and retinal hemorrhages around the disk but not into the retinal periphery.

  • Funduscopic abnormalities usually precede visual disturbances.

  • Do immediate neuroimaging and, if no mass lesion is seen, obtain CSF for analysis and measure CSF pressure with a lumbar puncture.

  • Treat the underlying disorder.

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