Merck Manual

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Introduction to Bullous Diseases

By

Daniel M. Peraza

, MD, Geisel School of Medicine at Dartmouth University

Last full review/revision Jun 2019| Content last modified Jun 2019
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Bullae are elevated, fluid-filled blisters ≥ 10 mm in diameter.

The autoimmune bullous diseases include

Although epidermolysis bullosa acquisita is thought to be an autoimmune disease, epidermolysis bullosa is a group of inherited diseases in which epithelial adhesion protein defects lead to epithelial fragility and bullae formation.

Other bullous conditions include staphylococcal scalded skin syndrome, toxic epidermal necrolysis, severe cellulitis, and certain drug eruptions.

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