Merck Manual

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Causes of Thrombocytopenia

Causes of Thrombocytopenia



Bone marrow does not produce enough platelets

Heavy alcohol consumption

Some bone marrow disorders

Some chemotherapy drugs

Platelets become diluted

Massive red blood cell replacement or exchange transfusion; stored red blood cells do not contain very many platelets

Use or destruction of platelets increases

Drugs such as heparin, quinine, many antibiotics (such as trimethoprim/sulfamethoxazole, rifampin, and vancomycin), and some oral drugs for diabetes

Some vaccines, such as measles, mumps, and rubella, , influenza, hepatitis B, COVID-19