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Chest Pain


Andrea D. Thompson

, MD, PhD, Department of Internal Medicine, Division of Cardiovascular Medicine, University of Michigan;

Michael J. Shea

, MD, Michigan Medicine at the University of Michigan

Last full review/revision Sep 2020| Content last modified Sep 2020
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Topic Resources

Chest pain is a very common complaint. Many patients are well aware that it is a warning of potential life-threatening disorders and seek evaluation for minimal symptoms. Other patients, including many with serious disease, minimize or ignore its warnings. Pain perception (both character and severity) varies greatly between individuals as well as between men and women. However described, chest pain should never be dismissed without an explanation of its cause.

Pathophysiology of Chest Pain

The heart, lungs, esophagus, and great vessels provide afferent visceral input through the same thoracic autonomic ganglia. A painful stimulus in these organs is typically perceived as originating in the chest, but because afferent nerve fibers overlap in the dorsal ganglia, thoracic pain may be felt (as referred pain) anywhere between the umbilicus and the ear, including the upper extremities.

Painful stimuli from thoracic organs can cause discomfort described as pressure, tearing, gas with the urge to eructate, indigestion, burning or aching. Uncommonly, other descriptions of chest pain are given such as stabbing or sharp needle-like pain. When the sensation is visceral in origin, many patients deny they are having pain and insist it is merely “discomfort.”

Etiology of Chest Pain

Many disorders cause chest pain or discomfort. These disorders may involve the cardiovascular, gastrointestinal, pulmonary, neurologic, or musculoskeletal systems (see table Some Causes of Chest Pain).

Some disorders are immediately life threatening:

Other causes range from serious, potential threats to life to causes that are simply uncomfortable. Often no cause can be confirmed even after full evaluation.

Overall, the most common causes are

In some cases, no etiology of the chest pain can be determined.


Some Causes of Chest Pain


Suggestive Findings

Diagnostic Approach†


Acute, crushing pain radiating to the jaw or arm

Exertional pain relieved by rest (angina pectoris)

S4 gallop

Sometimes systolic murmurs of mitral regurgitation

Often red flag findings‡

Serial ECGs and cardiac markers

Sometimes echocardiogram

Stress imaging test or CT angiography considered in patients with negative or unchanged ECG findings and no cardiac marker elevation on serial testing

Often heart catheterization and coronary angiography if findings are positive

1Thoracic aortic dissection

Sudden, tearing pain radiating to the back

Some patients have syncope, stroke, or leg ischemia

Pulse or BP that may be unequal in extremities

Age > 55


Red flag findings‡

Chest x-ray with findings suggesting diagnosis

Enhanced CT scan of aorta for confirmation

Fever, dyspnea, fatigue, chest pain (if myopericarditis), recent viral or other infection

Sometimes findings of heart failure, pericarditis, or both


Serum cardiac markers


C-reactive protein

Usually echocardiography or cardiac MRI

Constant or intermittent sharp pain often aggravated by breathing, swallowing food, or supine position and relieved by sitting or leaning forward

Pericardial friction rub

Jugular venous distention


Serum cardiac markers (sometimes showing minimal elevation of troponin and CK-MB levels if associated myocarditis present)

Transthoracic echocardiography


Sudden, severe pain following vomiting or instrumentation (eg, esophagogastroscopy or transesophageal echocardiography)

Subcutaneous crepitus detected during auscultation

Multiple red flag findings‡

Chest x-ray

Esophagography with water-soluble contrast for confirmation

Pain in the epigastrium or lower chest that is often worse when lying flat and is relieved by leaning forward


Upper abdominal tenderness


Often history of alcohol abuse or biliary tract disease

Serum lipase

Abdominal CT

Recurrent right upper quadrant or epigastric discomfort following meals (but not exertion)

Ultrasonography of gallbladder

Sometimes cholescintigraphy

Long-standing pain of insidious onset that may or may not accompany swallowing

Usually also difficulty swallowing

Barium swallow

Recurrent burning pain radiating from epigastrium to throat that is exacerbated by bending down or lying down and relieved by antacids

Clinical evaluation

Sometimes endoscopy

Sometimes motility studies

Recurrent, vague epigastric discomfort,particularly in a patient who smokes or uses alcohol excessively, that is relieved by food, antacids, or both

No red flag findings‡

Sometimes endoscopy

Clinical evaluation

Sometimes testing for Helicobacter pylori


Often pleuritic pain, dyspnea, tachycardia

Sometimes mild fever, hemoptysis, shock

More likely when risk factors are present

Varies with clinical suspicion (Wells criteria)

Sometimes D-dimer

Sometimes CT pulmonary angiography

Significant dyspnea, hypotension, neck vein distention, unilateral diminished breath sounds and hyperresonance to percussion

Sometimes subcutaneous air

Usually clinical

Obvious on chest x-ray

Fever, chills, cough, and purulent sputum

Often dyspnea, tachycardia, signs of consolidation

Chest x-ray

Sometimes, unilateral diminished breath sounds, subcutaneous air

Chest x-ray

Sometimes ultrasonography or chest CT


May have preceding pneumonia, pulmonary embolism, or viral respiratory infection

Pain with breathing, cough

Sometimes a pleural rub, but otherwise examination unremarkable

Usually clinical evaluation


2Various thoracic cancers

Variable but sometimes pleuritic pain

Sometimes chronic cough, smoking history, signs of chronic illness (weight loss, fever), cervical lymphadenopathy

Chest x-ray

Chest CT if x-ray findings are suggestive

Bone scan considered for persistent, focal rib pain

Nearly constant pain, affecting multiple areas of the body as well as the chest

Typically, fatigue and poor sleep

Multiple trigger points

Clinical evaluation

3Herpes zoster infection

Sharp, band-like pain in the thorax unilaterally

Classic linear, vesicular rash

Pain may precede rash by several days

Clinical evaluation

3Musculoskeletal chest wall pain (eg, due to trauma, overuse, or costochondritis)

Often suggested by history

Pain typically persistent (typically days or longer), worsened with passive and active motion

Diffuse or focal tenderness

Clinical evaluation


Various features

No red flag findings‡

Diagnosis of exclusion

* Seriousness of causes varies as indicated:

1 Immediate life threats.

2 Potential life threats.

3 Uncomfortable but usually not dangerous.

† Most patients with chest pain should have pulse oximetry, ECG, and chest x-ray (basic tests). If there is suspicion of coronary ischemia, serum cardiac markers (troponin, CK-MB) should also be checked.

‡ Red flag findings include abnormal vital signs (tachycardia, bradycardia, tachypnea, hypotension), signs of hypoperfusion (eg, confusion, ashen color, diaphoresis), shortness of breath, asymmetric breath sounds or pulses, new heart murmurs, or pulsus paradoxus > 10 mm Hg.

CK-MB = creatine kinase-MB isoenzyme; ESR = erythrocyte sedimentation rate; S4 = 4th heart sound.

Evaluation of Chest Pain


History of present illness should note the location, duration, character, and quality of the pain. The patient should be asked about any precipitating events (eg, straining or overuse of chest muscles), as well as any triggering and relieving factors. Specific factors to note include whether pain is present during exertion or at rest, presence of psychologic stress, whether pain occurs during respiration or coughing, difficulty swallowing, relationship to meals, and positions that relieve or exacerbate pain (eg, lying flat, leaning forward). Previous similar episodes and their circumstances should be noted with attention to the similarity or lack thereof and whether the episodes are increasing in frequency and/or duration. Important associated symptoms to seek include dyspnea, palpitations, syncope, diaphoresis, nausea or vomiting, cough, fever, and chills.

Review of systems should seek symptoms of possible causes, including leg pain, swelling, or both (deep venous thrombosis [DVT] and therefore possible pulmonary embolism) and chronic weakness, malaise, and weight loss (cancer).

Past medical history should document known causes, particularly cardiovascular and gastrointestinal (GI) disorders, and any cardiac investigations or procedures (eg, stress testing, catheterization). Risk factors for coronary artery disease (CAD—eg, hypertension, dyslipidemia, diabetes, cerebrovascular disease, tobacco use) or pulmonary embolism (eg, lower extremity injury, recent surgery, immobilization, known cancer, pregnancy) should also be noted.

Drug history should note use of drugs that can trigger coronary artery spasm (eg, cocaine, triptans) or GI disease (particularly alcohol, nonsteroidal anti-inflammatory drugs).

Family history should note history of myocardial infarction (particularly among 1st-degree relatives at an early age, ie, < 55 in men and < 60 in women) and hyperlipidemia.

Physical examination

Vital signs and weight are measured, and body mass index (BMI) is calculated. Pulses are palpated in both arms and both legs, blood pressure is measured in both arms, and pulsus paradoxus is measured.

General appearance is noted (eg, pallor, diaphoresis, cyanosis, anxiety).

Neck is inspected for venous distention and hepatojugular reflux, and the venous wave forms are noted. The neck is palpated for carotid pulses, lymphadenopathy, or thyroid abnormality. The carotid arteries are auscultated for bruit.

Lungs are percussed and auscultated for presence and symmetry of breath sounds, signs of congestion (dry or wet crackles, rhonchi), consolidation (pectoriloquy), pleural friction rubs, and effusion (decreased breath sounds, dullness to percussion).

The cardiac examination notes the intensity and timing of the 1st heart sound (S1) and 2nd heart sound (S2), the respiratory movement of the pulmonic component of S2, pericardial friction rubs, murmurs, and gallops. When murmurs are detected, the timing, duration, pitch, shape, and intensity and the response to changes of position, handgrip, and the Valsalva maneuver should be noted. When gallops are detected, differentiation should be made between the 4th heart sound (S4), which is often present with diastolic dysfunction or myocardial ischemia, and the 3rd heart sound (S3), which is present with systolic dysfunction.

The chest is inspected for skin lesions of trauma or herpes zoster infection and palpated for crepitance (suggesting subcutaneous air) and tenderness. The abdomen is palpated for tenderness, organomegaly, and masses or tenderness, particularly in the epigastric and right upper quadrant regions.

The legs are examined for arterial pulses, adequacy of perfusion, edema, varicose veins, and signs of DVT (eg, swelling, erythema, tenderness).

Red flags

Certain findings raise suspicion of a more serious etiology of chest pain:

  • Abnormal vital signs (tachycardia, bradycardia, tachypnea, hypotension)

  • Signs of hypoperfusion (eg, confusion, ashen color, diaphoresis)

  • Shortness of breath

  • Hypoxemia on pulse oximetry

  • Asymmetric breath sounds or pulses

  • New heart murmurs

  • Pulsus paradoxus > 10 mm Hg

Interpretation of findings

Symptoms and signs of thoracic disorders vary greatly, and those of serious and nonserious conditions often overlap. Although red flag findings indicate a high likelihood of serious disease, and many disorders have “classic” manifestations (see table Some Causes of Chest Pain), many patients who have serious illness do not present with these classic symptoms and signs. For example, patients with myocardial ischemia may complain only of indigestion or have a very tender chest wall on palpation. A high index of suspicion is important when evaluating patients with chest pain. Nonetheless, some distinctions and generalizations are possible.

Duration of pain can provide clues to the severity of the disorder. Long-standing pain (ie, for weeks or months) is not a manifestation of a disorder that is immediately life threatening. Such pain is often musculoskeletal in origin, although gastrointestinal origin or a cancer should be considered, particularly in patients who are older. Similarly, brief (< 5 seconds), sharp, intermittent pains rarely result from serious disorders. Serious disorders typically manifest pain lasting minutes to hours, although episodes may be recurrent (eg, unstable angina may cause several bouts of pain over 1 or more days).

Patient age is helpful in evaluating chest pain. Chest pain in children and young adults (< 30 years) is less likely to result from myocardial ischemia, although myocardial infarction can occur in people in their 20s. Musculoskeletal and pulmonary disorders are more common causes in these age groups.

Exacerbation and relief of symptoms also are helpful in evaluating chest pain. Although angina can be felt anywhere between the ear and the umbilicus, it is typically consistently related to physical or emotional stress, ie, patients do not experience angina from climbing one flight of stairs one day and tolerate 3 flights the next day. Nocturnal angina is characteristic of acute coronary syndromes, heart failure, or coronary artery spasm.

Pain from many disorders, both serious and minor, can be exacerbated by respiration, movement, or palpation of the chest. These findings are not specific for origin in the chest wall; about 15% of patients with acute myocardial infarction have chest tenderness on palpation.

Nitroglycerin may relieve pain of both myocardial ischemia and noncardiac smooth muscle spasm (eg, esophageal or biliary disorders); its efficacy or lack thereof should not be used for diagnosis.

Associated findings may also suggest a cause. Fever is nonspecific but, if accompanied by cough, suggests a pulmonary cause. Patients with Raynaud syndrome or migraine headaches sometimes have coronary spasm.

The presence or absence of risk factors for CAD (eg, hypertension, hypercholesterolemia, smoking, obesity, diabetes, positive family history) alters the probability of underlying CAD but does not help diagnose the cause of a given episode of acute chest pain. Patients with those factors may well have another cause of chest pain, and patients without them may have an acute coronary syndrome. However, known CAD in a patient with chest pain raises the likelihood of that diagnosis as the cause (particularly if the patient describes the symptoms as “like my angina” or “like my last heart attack”). A history of peripheral vascular disease also raises the likelihood that angina is the cause of chest pain.


For adults with acute chest pain, immediate life threats must be ruled out. Most patients should initially have pulse oximetry, ECG, and chest x-ray. In patients with hemodynamic instability, a bedside echocardiogram can also be useful in further evaluating potential life-threatening causes.

If symptoms suggest an acute coronary syndrome or if no other cause is clear (particularly in at-risk patients), troponin levels are measured. Expeditious evaluation is essential because if myocardial infarction or other acute coronary syndrome is present, the patient should be considered for urgent heart catheterization (when available). Immediate catheterization is indicated in patients with ST-elevation on ECG, non–ST-segment elevation myocardial infarction (NSTEMI) causing hypotension, ventricular arrhythmias, or persistent chest pain despite optimal medical management.

Some abnormal findings on these tests confirm a diagnosis (eg, acute myocardial infarction, pneumothorax, pneumonia). Other abnormalities suggest a diagnosis or at least the need to pursue further investigation (eg, abnormal aortic contour on chest x-ray suggests need for testing for thoracic aortic dissection). Thus, if these initial test results are normal, thoracic aortic dissection, tension pneumothorax, and esophageal rupture are highly unlikely. However, in acute coronary syndromes, ECG may not change for several hours or sometimes not at all, and in PE, oxygenation may be normal. Thus, other studies may need to be obtained based on findings from the history and physical examination (see table Some Causes of Chest Pain).

Because a single normal set of cardiac markers does not rule out a cardiac cause, patients whose symptoms suggest an acute coronary syndrome should have serial measurement of the cardiac marker troponin and ECGs at least 4 hours apart. Drug treatment for suspected acute coronary syndrome is begun while awaiting results of the 2nd troponin level unless there is a clear contraindication. A diagnostic trial of sublingual nitroglycerin or an oral liquid antacid does not adequately differentiate myocardial ischemia from gastroesophageal reflux disease or gastritis. Either drug may relieve symptoms of either disorder.

Troponin will be elevated in all acute coronary syndromes causing cardiac injury and often in other disorders that damage the myocardium (eg, myocarditis, pericarditis, aortic dissection involving coronary artery flow, pulmonary embolism, heart failure, severe sepsis). Creatine kinase (CK) may be elevated due to damage to any muscle tissue, but creatine kinase-MB isoenzyme (CK-MB) elevation is specific to damage to the myocardium. However, troponin is now the standard marker of cardiac muscle injury. Advances in high-sensitivity troponin assays may allow for more rapid serial evaluation of a possible acute coronary syndrome. With improved negative predictive value, high sensitivity troponin also has the potential to decrease the necessity of further testing in patients with negative biomarkers and has been demonstrated to allow patients to be discharged more quickly (1). ST-segment abnormality on the ECG may be nonspecific or due to antecedent disorders, so comparison with previous ECGs is important. Some clinicians follow initial testing (acutely or within several days) with a stress ECG or a stress imaging test.

If a pulmonary embolism (PE) is considered possible, D-dimer testing is done in low- and intermediate-risk patients. The likelihood of pulmonary embolism is affected by a number of clinical factors, which can be used to derive an approach to testing. Many of these factors are included in scoring systems that help determine the probability of PE such as the Modified Wells Scoring System, the Revised Geneva Scoring System, and the Pulmonary Embolism Rule Out Criteria (PERC).

In patients with chronic chest pain, immediate threats to life are unlikely. Most clinicians initially obtain a chest x-ray and do other tests based on symptoms and signs.

Diagnosis reference

Treatment of Chest Pain

Specific identified disorders are treated. If etiology is not clearly benign, patients are usually admitted to the hospital or an observation unit for cardiac monitoring and more extensive evaluation. Pain is treated with acetaminophen or opioids as needed, pending a diagnosis. Pain relief following opioid treatment should not diminish the urgency of ruling out serious and life-threatening disease.

Geriatrics Essentials

The probability of serious and life-threatening disease increases with age. Many older patients recover more slowly than younger patients but survive for significant time if properly diagnosed and treated. Drug doses are usually lower, and rapidity of dose escalation is slower. Chronic disorders (eg, chronic kidney disease) are often present and may complicate diagnosis and treatment.

Key Points

  • Immediate life threats must be ruled out first.

  • Some serious disorders, particularly coronary ischemia and pulmonary embolism, often do not have a classic presentation.

  • Most patients should have pulse oximetry, ECG, cardiac marker measurement, and chest x-ray.

  • Evaluation must be prompt so that patients with ST-elevation myocardial infarction or other criteria for intervention can be in the heart catheterization laboratory (or have thrombolysis) within the 90-minute standard.

  • If PE is highly likely, antithrombin drugs should be given while the diagnosis is pursued; another embolus in a patient who is not receiving anticoagulants may be fatal.

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